Finland finds new method for detection of Alzheimer's disease

Alzheimer's disease (Alzheimer's disease) is currently incurable, so early detection and early treatment are important. Finnish researchers recently discovered that detection of the disease can be detected several months or even years before the onset of symptoms.

The Finnish National Technical Research Center issued a press communique on the 14th that a study jointly completed by the Center and the University of Eastern Finland found that a molecular signal indicating tissue hypoxia and the pentose phosphate pathway is a precursor to Alzheimer's disease. The so-called pentose phosphate pathway is a way of oxidative decomposition of glucose.

The communique said that the researchers collected serum samples of patients with Alzheimer's disease, mild cognitive impairment and healthy controls, and followed them. Within 27 months, 52 of 143 patients with mild cognitive impairment developed Alzheimer's disease. A molecular signal indicating tissue hypoxia and the pentose phosphate pathway can be detected in these 52 human serum samples. By analyzing the metabolic pathways, the researchers found that the pentose phosphate pathway is associated with Alzheimer's disease. Tissue hypoxia and oxidative stress are the reflections of early lesions.

Finnish National Technology Research Center pointed out that doctors can assess the patient's neurocognitive function in conjunction with this serum detection method to identify high-risk patients in need of comprehensive treatment.

Alzheimer's disease is a brain disease, and the cause of the disease is not yet clear. Clinical symptoms include cognitive, memory, and language dysfunction. There is currently no effective cure, and existing drugs can only relieve symptoms and slow the progression of the disease.

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